With a length of approximately 7 meters and a size of around 300m², the gut is the largest internal organ of the body. It hosts a complex ecosystem of trillions of microorganisms that make up our gut flora. These play a crucial role in digestion, nutrient absorption, and even in regulating our mood and immune system.
Gut flora, also known as the gut microbiome, refers to the trillions of microorganisms that inhabit our gut. Our gut microbiome is as individual as we are. It is influenced by a variety of factors, such as our genetics, diet, environment, and lifestyle.
In an adult, the total weight of all microorganisms living in the gut can amount to a hefty 1 to 2 kg.
The gut flora hosts bacteria, but also fungi, viruses, and other microbes, which are mainly found in our large intestine.
It is estimated that there are up to 2,000 different gut bacteria. There are both "good" and "bad" bacteria, and the balance between them is crucial for our health. Good bacteria, such as Lactobacillus and Bifidobacteria, help digest food, produce vitamins, strengthen the immune system, and protect us from harmful pathogens. They are like the guardians of our gut tract, ensuring everything runs smoothly. The richer and more diverse the good gut bacteria in the gut flora, the more stable our gut microbiome is.
On the other hand, there are also bad gut bacteria, such as coliform bacteria. These gut bacteria can cause digestive issues and inflammation and weaken our immune system if they take over the gut.
Research has only been intensively focusing on the influence of gut flora on our health and wellbeing for a few years. Nevertheless, there are already some insights that highlight the importance of the gut:
One of the most obvious functions of our gut flora is its role in digesting food and absorbing essential nutrients. Gut bacteria break down complex carbohydrates, proteins, and fats into simpler compounds that our body can absorb. This process begins in the mouth with the chewing of food and mixing with saliva, continues in the stomach where enzymes and stomach acid aid digestion, and finally takes place in the small intestine where nutrients are absorbed into the bloodstream through the intestinal wall. Subsequently, all organs and cells are supplied with vitamins and minerals through the blood.
The gut flora plays a crucial role in the development and regulation of our immune system. About 70% of our immune system is located in the gut,*1 where it is constantly in contact with bacteria, viruses, and other potential pathogens. The intestinal wall forms a barrier against harmful intruders and hosts a variety of immune cells that fight infections and regulate inflammation. A healthy balance of gut bacteria is crucial for the production of immune cells and the defense against pathogens. A disturbed gut flora can, in turn, weaken the immune system and increase the risk of infections.
You may have heard of the "gut-brain axis" – the connection between our gut and our brain. The gut is therefore also referred to as the "second brain." This connection is not just a metaphor but a scientifically supported phenomenon. It describes the complex communication between our gut and our brain. This communication takes place through various channels, such as nerve pathways, hormones, and the immune system. There is increasing evidence that the gut flora can influence our mood, stress levels, and even our behavior. Moreover, a disturbed gut flora has been linked to neurological disorders such as Parkinson's, depression, and autism.*2
Certain bacteria in the gut are capable of producing vitamins essential for our health. These include, for example, B vitamins, vitamin K, and folic acid.
The gut is also involved in the production of hormones that regulate various physiological processes in the body. For example, the gut produces the happiness hormone serotonin, which not only affects mood but also regulates gut motility and appetite control.
Another important contribution of the gut to our health is the removal of toxins and harmful substances from the body. The gut flora can neutralize toxic substances and promote their excretion, reducing the risk of damage to the cells and organs of the body. This process is important for detoxification and protection against environmental pollutants and toxins we encounter daily.
Our gut produces a large portion of the happiness hormone serotonin, which is a precursor to melatonin, the so-called "sleep hormone." Melatonin regulates your sleep-wake cycle and ensures you can fall asleep and stay asleep well. A healthy gut flora can optimize serotonin production, which in turn stimulates melatonin production and thus can improve your sleep.
Japanese researchers examined in a study the influence of good gut bacteria (Lactobacilli) on sleep quality during exam stress.*3 In the placebo-controlled study, it was shown that daily intake of beneficial gut bacteria significantly increased sleep duration. At the same time, participants felt more refreshed and alert after waking up.
A number of factors can disrupt the balance of our gut flora by promoting the growth of bad gut bacteria:
A disturbed balance of the gut flora, also known as dysbiosis, can lead to digestive issues such as bloating, diarrhea, or constipation. However, the effects extend far beyond the gut. Studies suggest that dysbiosis can be associated with a range of conditions, such as irritable bowel syndrome, chronic inflammatory bowel diseases, mental illnesses, and cardiovascular diseases.*4
*1 https://www.bzfe.de/ernaehrung/ernaehrungswissen/gesundheit/das-immunsystem-staerken/
*2 https://www.bmel.de/SharedDocs/Downloads/DE/Broschueren/Kompassernaehrung/kompass-ernaehrung-3-2021.pdf?__blob=publicationFile&v=3
*3 https://pubmed.ncbi.nlm.nih.gov/28443383/
*4 https://karger.com/kai/article/4/2/47/824390/Die-Rolle-des-Darmmikrobioms-bei-chronischen